The Brain and Alzheimer's Disease

Alzheimer's disease attacks nerve cells in several regions of the brain.

A. Cerebral Cortex:
Involved in conscious thought and language.
B. Basal forebrain:
Has large numbers of neurons containing acetylcholine, a chemical important in memory and learning.
C. Hippocampus:
Essential to memory storage. The earliest signs of Alzheimer's are found in the nearby entorhinal cortex (not shown).

Hallmarks of Alzheimer's disease
include neuritic plaques,
(outside neurons), and
neurofibrillary tangles
(inside neurons).




Natural Treatments:

Doctors are studying a couple of nutrients as potential treatments for Alzheimer's disease. Here's what they recommend, based on very preliminary research.



Fighting the Memory Thief
Few health problems are as feared as Alzheimer's disease. The fourth leading cause of death in adults (after heart disease, cancer and stroke), Alzheimer's affects approximately four million Americans. And this figure is expected to more than triple by the middle of the next century.

Alzheimer's is a disease that sneaks up slowly, ever so quietly stealing away an elderly person's memory and personality, eventually eroding his ability to take care of himself. Elderly people with Alzheimer's are then forced to rely on family or health care professionals for survival. Is there no hope?

Actually, yes, there is. A cure is probably decades away. But even in the high-tech world of brain research, some of the most promising treatments on the horizon actually include the use of a few simple vitamins.

Investigating an Elusive Enemy
A look at what's going on in the brain of someone with Alzheimer's disease makes the memory loss and other personality problems at least understandable. Once-healthy brain cells get tangled into knots and die off. Far less clear is just what's killing those cells. For years, research focused on microscopic plaques, made of a substance called amyloid, that slowly build up in the area of the brain responsible for memory and mental functioning. Once the plaques start hardening, the havoc begins.

As it turns out, amyloid probably has quite a few partners in crime--and at least one could be hiding in your family tree. Some forms of a blood protein called ApoE that normally ferry cholesterol through the blood also appear to cause more amyloid to be deposited in the brain and may help it harden. And the evidence implicating one form, ApoE-4, as a risk factor for this disease is convincing. Folks with two ApoE-4 genes are eight times as likely to develop Alzheimer's as those who inherit only ApoE-2 or ApoE-3. In one study of 46 adults with Alzheimer's, 21.4 percent had the requisite two ApoE-4 genes compared with 2.9 percent who had no ApoE-4 genes.

Other researchers think zinc can potentially increase the amount of toxic amyloid deposited in the brain. In lab experiments, investigators at Massachusetts General Hospital in Boston found that a slight increase in zinc caused amyloid "to curdle into gluelike clumps" within just two minutes. More information is needed on the role of dietary zinc in Alzheimer's, according to the study's lead researcher. But now there is enough evidence to warn against megadoses of elemental zinc. Because increased dietary zinc has been shown to markedly decrease mental functioning in people with Alzheimer's, they get no more than the Daily Value of 15 milligrams.

During studies in the 1960s, animals injected with aluminum developed tangles similar to those found in people with Alzheimer's. Since then, studies using advanced measuring devices have found increased concentrations of aluminum in brain tissue obtained from people who had died from Alzheimer's, we still don't know where the aluminum is from or what it's doing there, but we're trying to determine whether it has an active role.

Brain Rust Sets In
No matter what the cause of Alzheimer's may ultimately be, some researchers are convinced that the oxidative damage your brain suffers over a lifetime also plays a role in the development of this disease. When the body burns oxygen to produce energy, the process also spawns chemically unstable molecules that are known as free radicals. These molecules steal electrons from your body's healthy molecules to balance themselves, damaging all kinds of cells, including brain cells, in the process.

A number of things contribute to the production of free radicals: pollution, cigarette smoke, alcohol--in other words, living in the late twentieth century. Oxidative damage is important is that one of the main risk factors for Alzheimer's is getting old. Oxidative damage accumulates during aging just from normal metabolism of brain cells.

In fact, 10 percent of people ages 65 and older have Alzheimer's, while 20 percent of those over age 75 have the disease. A whopping 40 percent of those over age 85 have it.

One theory suggests that the oxidation process might make amyloid even more damaging--and might kill some brain cells on its own.

Further complicating the search for an Alzheimer's cure: ApoE-4, zinc, aluminum, oxidation and even inflammation may each play some small role in causing the disease in all people who have the disease. 
Vitamin E Might Provide Some Protection
While researchers explore different approaches for conquering Alzheimer's, at least one research team has turned to a vitamin breakthrough in stroke treatment for answers.

During a stroke, damaged brain cells release a neurotransmitter called glutamic acid. This chemical causes a chain reaction that destroys more brain cells, releasing even more dangerous glutamic acid.

Exposing brain cells to vitamin E in the laboratory seems to shield them from the effects of a stroke, vitamin E actually has a protective effect on brain cells, limiting the number killed by the glutamic acid.

In another study,  bathing brain cells in vitamin E protects them from a toxic protein found in amyloid plaques.

How? Just as soaking a peeled apple in lemon juice prevents oxidation from turning it brown, antioxidants such as vitamin E protect brain cells by neutralizing free radicals.

There's a hitch, however, in using vitamin E to prevent and treat Alzheimer's. Vitamin E doesn't cross what's called the blood-brain barrier very well. A natural protective mechanism, this barrier literally shields the brain from most substances. It's a problem. Vitamin E is not the ideal compound to use in any type of therapy in this respect.

In the quest for a cure, however, researchers are attempting to fuse vitamin E with something like a steroid so that it can cross your blood-brain barrier more effectively.

It's too early to tell whether vitamin E supplements alone can help ward off Alzheimer's disease. But there's enough potential to warrant taking supplements. Vitamin E is pretty hard to get in your diet, because it's primarily in vegetable oils and if you don't eat enough, the vitamin E in your blood and brain actually decreases as you get older. That can be elevated somewhat by vitamin E supplements.

Although you should see your doctor first, about 400 international units of vitamin E a day should be enough for most people. The Daily Value for vitamin E is 30 international units.

The Thiamin Connection
While vitamin E researchers try to protect the brain against the ravages of amyloid plaques, those studying thiamin have taken a different approach: improving the memory of people with Alzheimer's.

In one study, 11 people with Alzheimer's symptoms were directed to take either 1,000 milligrams of thiamin or placebos (look-alike dummy pills) three times a day for three months. (This is a lot of thiamin, as the Daily Value is just 1.5 milligrams!) Tests before and after the study showed that memory improved slightly for those taking thiamin.

That might not seem like a particularly impressive finding. But people in the later stages of Alzheimer's disease generally experience a significant drop in mental functioning every six months. 

In another study researchers at the Medical College of Georgia in Augusta treated 18 Alzheimer's patients for five months with megadoses of thiamin ranging from 3,000 to 8,000 milligrams a day, with the dose changing from month to month.

At the end of each month, the participants took a brief bedside exam that included questions about the date, the name of the hospital and the city, county and state. When the results were in, the research team discovered that some participants improved slightly the month they took 5,000 milligrams of thiamin a day.

Why might something like thiamin help protect memory? It's possible that thiamin helps make an important neurotransmitter called acetylcholine more available in the brain. Acetylcholine helps the nerve impulses that carry thought leap across the gaps between brain cells. And acetylcholine is lower in people with Alzheimer's. Interestingly, research shows thiamin deficiency in older folks may run as high as 37 percent.

Does this mean that people with Alzheimer's could benefit from taking large doses of thiamin? Much more research needs to be done before answering that question for sure. The effect of the treatment is not tremendous in and of itself, but it looks like it's an innocuous treatment and of mild benefit. Taking 5,000 milligrams of thiamin a day caused only mild nausea in some people. If you or a family member would like to try this therapy, make sure you discuss it with your doctor.

Research has so far revealed very little about the impact of nutrition on Alzheimer's. If you are concerned about aluminum, you may wish to check out your water and cookware.

Watch your water.The possible connection between Alzheimer's and aluminum is still controversial and hotly debated. While many foods contain aluminum from leavening agents such as baking powder, concern over aluminum has often focused on water. Over 50 percent of the municipal water supplies in the United States use a form of aluminum to help remove contaminants. Does that mean you have to worry about aluminum in your drinking water? Perhaps.

If the water is purified properly, there shouldn't be any problem, the process removes both the natural aluminum and that used for purification. But the question is, how much of it is done properly? 

If you are concerned about aluminum in your drinking water, you can have your water tested. One place to call is the National Testing Laboratory at 1-800-426-8378 or 1-800-458-3330. The laboratory's Watercheck tests for 74 chemicals, including aluminum, and for physical factors such as acidity.

Fix some finger foods. What a difference a meat loaf sandwich can make! When a dietitian at a Toledo, Ohio, nursing home noticed that the facility's Alzheimer's patients were losing an unhealthy amount of weight, she reduced the number of foods in their diets that required utensils--meats that needed cutting, for example--and added things such as meat loaf sandwiches, which were easy to handle. A review of the patients' records, conducted by a food and nutrition professor at Bowling Green State University in Ohio, found that the dietary changes helped these people maintain their weight. The new foods also decreased frustration, increased morale and, as a result, increased consumption of food--always the best source of important vitamins and minerals.


Disclaimer: This information is intended as a guide only.   This information is offered to you with the understanding that it not be interpreted as medical or professional advice.  All medical information needs to be carefully reviewed with your health care provider.


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